Summary
This preliminary report supports the feasibility of performing MRI/magnetic resonance cholangiopancreatographies-based PC screening as part of a clinical trial in a community setting. A longer follow-up is needed to better assess safety and efficacy.
Original Article
A Community-Based Pancreatic Cancer Screening Study in High-Risk Individuals: Preliminary Efficacy and Safety Results
Clinical and Translational Gastroenterology
Kandiah, Jonathan MD; Lo, Tammy APRN; Jin, Dugho MD; Melchior, Landon MD; Krebs, Thorsten L. MD; Anand, Naveen MD; Ingram, Susan MS; Krumholtz, Pramila RN; Pandya, Deep MS; Trinidad, Antolin MD; Dong, Xiang (Eric) MD; Seshadri, Ramanathan MD; Bauman, James MD; Lee, Ronald MD; Frank, Richard C. MD
Abstract
INTRODUCTION:
Pancreatic cancer (PC) screening recommendations have been based on studies performed solely at high-volume academic centers. To make PC screening more widely available, community-based efforts are essential. We implemented a prospective PC screening study in the community of Fairfield County, CT, and report our early safety and efficacy results.
METHODS:
Eligible individuals were enrolled into an investigator-initiated study and underwent a baseline and 3 annual magnetic resonance imagings/magnetic resonance cholangiopancreatographies (MRIs/MRCPs) with gadolinium, biannual blood donations for biobanking, and assessments for anxiety and depression. All MRIs were presented at a multidisciplinary board to determine whether further investigation was warranted.
RESULTS:
Seventy-five individuals have been enrolled and 201 MRIs performed over a 2.6-year average length of follow-up. Abnormal pancreatic findings (predominantly small cysts) were detected in 58.7% of the participants. Among these, 6.7% underwent endoscopic ultrasound, with 1 case complicated by postprocedural pancreatitis. One surgical resection was performed on a 4.7-cm intraductal papillary mucinous neoplasm with a focus on low-grade pancreatic intraepithelial neoplasia. One incidental finding of fibrosing mediastinitis was detected. Anxiety and depression scores decreased over the course of this study from 21.4% to 5.4% and 10.7% to 3.6%, respectively.
DISCUSSION:
This preliminary report supports the feasibility of performing MRI/magnetic resonance cholangiopancreatographies-based PC screening as part of a clinical trial in a community setting. A longer follow-up is needed to better assess safety and efficacy. To the best of our knowledge, this is the first report from a community-based PC screening effort (clinicaltrials.gov ID: NCT03250078).
Specific author contributions: J.K.: drafting and editing the manuscript and interpreting data. T.L.: study planning and design, collecting and interpreting data, and writing the manuscript. D.J.: collecting and interpreting data and writing the manuscript. L.M.: interpreting data. T.L.K.: interpreting data. N.A.: collecting and interpreting data and writing and editing the manuscript. S.I.: collecting and interpreting data and editing the manuscript. P.K.: collecting data and editing the manuscript. D.P.: interpreting data, performed data analysis, and writing and editing the manuscript. A.T.: collecting and interpreting data and writing and editing the manuscript. X.D.: interpreting data and editing the manuscript. R.S.: interpreting data and editing the manuscript. J.B.: collecting and interpreting data and editing the manuscript. R.L.: collecting and interpreting data and editing the manuscript. R.C.F.: conceived and designed the study, collected and interpreted data, performed analysis, and contributed to writing and editing the manuscript.
Financial support: This work was supported by a Tribute to Pamela/The Naughton Family Fund, the Rallye for Pancreatic Cancer, and the Cornelia T. Bailey Foundation.