Summary
Statin use is associated with a potential tendency to improve BCR-free survival in prostate cancer and could reduce BCR in high-risk patients.
Original Article
The association of statin use and biochemical recurrence after curative treatment for prostate cancer.
A systematic review and meta-analysis
Medicine
Yin, Peng MD; Han, Sheng MD; Hu, Qingfeng MD; Tong, Shijun MD
Abstract
Objectives
To investigate the association between statin use and biochemical recurrence (BCR) in patients undergoing radical prostatectomy (RP) or radiotherapy (RT) as a curative treatment, a systematic review and meta-analysis was performed.
Methods
We conducted a literature search of online databases for studies assessing BCR associated with statin use in patients with prostate cancer undergoing RP or RT. We performed a pooled analysis of BCR-free survival with subgroup analysis of treatment, cancer risk, and medication.
Results
We identified 27 studies and found that statin use was associated with a potential tendency to improve BCR-free survival in patients undergoing curative treatment (P = .05). In addition, we revealed that statin use after curative treatment did not improve BCR-free survival (P = .33), whereas statin use could improve BCR-free survival in high-risk patients (P < .01).
Conclusions
Statin use is associated with a potential tendency to improve BCR-free survival in prostate cancer and could reduce BCR in high-risk patients.
Author contributions
Investigation: Peng Yin.
Resources: Peng Yin.
Software: Sheng Han, Qingfeng Hu, Shijun Tong.
Supervision: Qingfeng Hu, Shijun Tong.
Writing – original draft: Peng Yin.
Writing – review & editing: Qingfeng Hu.